"Post Covid Syndrome and Cognitive Dysfunction – Aetiology and Possible Treatment" - I think figure 1, the arrows going towards "cognitive dysfunction" should be bidirectional - but otherwise, yet another lay of the land paper implicitly but strongly suggesting that there is a pressing need for research focus on LC and ME/CFS treatments: https://cdn.fortunejournals.com/articles/post-covid-syndrome-and-cognitive-dysfunction-ndash-aetiology.pdf
#CognitiveDysfunction
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Marveling the Mysteries of Memory: How Our Brain Reactivates and Perceives Sensory Experiences
#MemoryMagic #SensoryPerception #Neuroscience #Hippocampus #CognitiveFunction #Neuroplasticity #OlfactorySenses #PTSD #EmotionalHealth #BrainScience #CognitiveDysfunction #MindAndBody #Neurotransmission #MemoryReactivation #MentalHealthMatters
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From HQ
Joe reminding us #trump's brain is fried.
FRIED.
FRIED.
Type I interferon signalling, cognition and neurodegeneration following COVID-19: update on a mechanistic pathogenetic model with implications for Alzheimer’s disease.
Selective vulnerability of neurogenesis sites to IFN-I dysregulation would then lead to clinical manifestations such as anosmia and cognitive impairment.
#Neurodegeneration #CognitiveDysfunction #IFNI
https://www.frontiersin.org/articles/10.3389/fnhum.2024.1352118/full
The Metal Dog #TheMetalDogArticleList
#BLABBERMOUTH
MICK MARS Refused To Believe He Would Be Confined To A Wheelchair
In a new interview with Jacqui Neal, MÖTLEY CRÜE guitarist Mick Mars spoke about his ongoing battle with degenerative disease ankylosing spondylitis (AS).
https://blabbermouth.net/news/mick-mars-refused-to-believe-he-would-be-confined-to-a-wheelchair
#LongCovid
##CognitiveDysfunction
"Such long-term issues were collectively referred to as “long Covid” and were reported to affect nearly every organ system.1 The cardinal features of long Covid include fatigue, dysautonomia (or postural orthostatic tachycardia syndrome), postexertional malaise, and cognitive difficulties that are colloquially referred to as “brain fog.”"
https://www.nejm.org/doi/full/10.1056/NEJMe2400189
#LongCovid mechanisms
#CognitiveDysfunction
"Long COVID has remained an on-going public health issue in the years following the global pandemic. Here, we report blood–brain barrier disruption in patients with acute SARS-CoV-2 infection and brain fog, and patients presenting with long COVID, brain fog and cognitive decline, compared to those with long COVID without any neurological symptoms."
NatureLeaky blood–brain barrier in long-COVID-associated brain fog - Nature NeuroscienceLong COVID has remained an on-going public health issue in the years following the global pandemic. Here, we report blood–brain barrier disruption in patients with acute SARS-CoV-2 infection and brain fog, and patients presenting with long COVID, brain fog and cognitive decline, compared to those with long COVID without any neurological symptoms.
#LongCovid mechanisms
#CognitiveDysfunction
"Here we show that BBB disruption is evident during acute infection and in patients with long COVID with cognitive impairment, commonly referred to as brain fog. Using dynamic contrast-enhanced magnetic resonance imaging, we show BBB disruption in patients with long COVID-associated brain fog"
NatureBlood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment - Nature NeuroscienceLong COVID is a major public health issue since 2020 and exhibits frequent neurological symptoms. Greene et al. propose that brain fog results from leaky brain blood vessels and a hyperactive immune system, shedding light on this phenomenon.
Replied to Javier Díaz-Nido
@Javier_DN Is it true that in societies where big families -sometimes 4 generations- live together, Alzheimers disease is less prevalent?
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Alzheimer
#CognitiveDecline #CognitiveDysfunction #Dementia #Hippocampus #Neuroimaging #NeuroImage #SocialIsolation #SocialBond
#Biomedicine #Health
Impact of social isolation on grey matter structure and cognitive functions: A population-based longitudinal neuroimaging study
Social isolation contributes to human brain atrophy and cognitive decline, indicating an opportunity to reduce dementia risk by promoting social networks.
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Alzheimer
#CognitiveDecline #CognitiveDysfunction #Dementia #Hippocampus #Neuroimaging #NeuroImage #SocialIsolation #SocialBond
#Biomedicine #Health
Social Bonds Protect Aging Brains
Social isolation can potentially harm brain structure and cognitive performance, suggesting an increased risk of conditions like Alzheimer’s dementia.
A lack of quality social interaction can lead to a decrease in the hippocampus’s volume, crucial for memory formation and retrieval, and poorer cognitive performance.
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Alzheimer
#CognitiveDecline #CognitiveDysfunction #Dementia #Hippocampus #Neuroimaging #NeuroImage #SocialIsolation #SocialBond
#Biomedicine #Health
https://neurosciencenews.com/social-aging-neuroscience-brain-23505/
Neuroscience NewsSocial Bonds Protect Aging Brains - Neuroscience NewsNeuroscience News provides research news for neuroscience, neurology, psychology, AI, brain science, mental health, robotics and cognitive sciences.
Running throughout Middle-Age Keeps Old Adult-Born Neurons Wired
Long-term running maintains the wiring of “old” new neurons, born during early adulthood, within a network that is important for memory function during aging in mice.
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neurogenesis #Neuron #BrainAging #Aging #MemoryLoss #CognitiveDecline #CognitiveDysfunction #PhysicalActivity #PhysicalExercise #Running
eNeuroRunning throughout Middle-Age Keeps Old Adult-Born Neurons WiredExercise may prevent or delay aging-related memory loss and neurodegeneration. In rodents, running increases the number of adult-born neurons in the dentate gyrus (DG) of the hippocampus, in association with improved synaptic plasticity and memory function. However, it is unclear whether adult-born neurons remain fully integrated into the hippocampal network during aging and whether long-term running affects their connectivity. To address this issue, we labeled proliferating DG neural progenitor cells with retrovirus expressing the avian TVA receptor in two-month-old sedentary and running male C57Bl/6 mice. More than six months later, we injected EnvA-pseudotyped rabies virus into the DG as a monosynaptic retrograde tracer, to selectively infect TVA expressing “old” new neurons. We identified and quantified the direct afferent inputs to these adult-born neurons within the hippocampus and (sub)cortical areas. Here, we show that long-term running substantially modifies the network of the neurons generated in young adult mice, upon middle-age. Exercise increases input from hippocampal interneurons onto “old” adult-born neurons, which may play a role in reducing aging-related hippocampal hyperexcitability. In addition, running prevents the loss of adult-born neuron innervation from perirhinal cortex, and increases input from subiculum and entorhinal cortex, brain areas that are essential for contextual and spatial memory. Thus, long-term running maintains the wiring of “old” new neurons, born during early adulthood, within a network that is important for memory function during aging.
Running Rewires the Aging Brain: Exercise Protects Memory Function
Physical activity, particularly running, has been found to rewire aging brains, helping to preserve memory functions.
Long-term running keeps older neurons wired, potentially preventing age-related memory loss and neurodegeneration.
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neurogenesis #Neuron #BrainAging #Aging #MemoryLoss #CognitiveDecline #CognitiveDysfunction #PhysicalActivity #PhysicalExercise #Running
https://neurosciencenews.com/running-neurogenesis-aging-23339/
Neuroscience NewsRunning Rewires the Aging Brain: Exercise Protects Memory Function - Neuroscience NewsNeuroscience News provides research news for neuroscience, neurology, psychology, AI, brain science, mental health, robotics and cognitive sciences.
Abundant Aβ fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer’s disease brains
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Astrocyte #Neuron #Alzheimer #CognitiveDecline #CognitiveDysfunction #MemoryLoss #BetaAmyloid #AmyloidFibrils #Aβ #AβFibrils #Immunotherapy #Lecanemab
Alzheimer’s Drug Lecanemab Shields Brain from Free-Roaming Amyloid Fibrils
Amyloid beta protein forms small aggregates that disrupt brain function in Alzheimer’s disease.
Lecanemab, a recently FDA-approved Alzheimer’s treatment, can neutralize these disruptive aggregates, hinting at its potential to slow down the disease’s cognitive decline.
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Astrocyte #Neuron #Alzheimer #CognitiveDecline #CognitiveDysfunction #MemoryLoss #BetaAmyloid #AmyloidFibrils #Immunotherapy #Lecanemab
https://neurosciencenews.com/amyloid-fibril-neuropharmacology-23207/
Neuroscience NewsAlzheimer's Drug Lecanemab Shields Brain from Free-Roaming Amyloid Fibrils - Neuroscience NewsNeuroscience News provides research news for neuroscience, neurology, psychology, AI, brain science, mental health, robotics and cognitive sciences.
Imaging Study Implicates Reactive Astrocyte-Neuron Interaction in Alzheimer’s Cognitive Decline
PET imaging with 11C-acetate and 18F-FDG was used to visualize the reactive astrocyte-induced acetate hypermetabolism and associated neuronal glucose hypometabolism in brains with neuroinflammation and Alzheimer’s Disease.
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Astrocyte #Neuron #Alzheimer #BrainImaging #Neuroimaging #NeuroMetabolism #AcetateHypermetabolism #GlucoseHypometabolism #NeuroInflammation #CognitiveDecline #CognitiveDysfunction
GEN - Genetic Engineering and Biotechnology NewsImaging Study Implicates Reactive Astrocyte-Neuron Interaction in Alzheimer’s Cognitive Decline
#Covid19 #CognitiveDysfunction #pwDementia
"In addition to finding that that all subtypes of dementia, irrespective of patients’ previous dementia types, behaved like rapidly progressive dementia following COVID-19, the team of investigators found that the line of demarcation between different types of dementia became remarkably blurry post-COVID-19."
Neuroscience News · COVID-19 Infection Accelerates the Progression of Dementia - Neuroscience NewsNeuroscience News provides research news for neuroscience, neurology, psychology, AI, brain science, mental health, robotics and cognitive sciences.
The 23th of April or the 2nd of March? #worldbookday
Anyway, my diseases stolen me one of my passion due to #brainfog. But I'm stubborn and I started reading last year again: comics instead thick books.
Web view has a translator but you can read the post using other options from your device.
#239 La sirena a la que se le mojaron los libros (leer con #DisfuncionCognitiva) 
https://domandoallobo.blogspot.com/2017/04/235-la-sirena-la-que-se-le-mojaron-los-libros.html
#Lupus #MyalgicEncephalomielitis #MEcfs #Sjögren #fibromyalgia #SAF #CognitiveDysfunction #blog
domandoallobo.blogspot.com#239 La sirena a la que se le mojaron los libros (leer con #brainfog)Blog Domando Al Lobo, Lupus Eritematoso Sistémico, LES, Síndrome de Fatiga Crónica, SFC, Enfermedad Sistémica de Intolerancia al Esfuerzo, ESIE. Systemic Exertion Intolerance Disorder, SEID, Fibromialgia, Síndrome de Sjögren, Trombocitopenia Autoinmune, blog de pacientes lupus, blog de pacientes fibromialgia, blog de pacientes síndrome de fatiga crónico, blog de pacientes síndrome de Sjögren, blog de pacientes síndromes de sensibilización central, Día Mundial del Libro 2017, Sant Jordi 2017, problemas para leer con brainfog, problemas para leer con disfunción cognitiva, leer con problemas de atención memoria concentración retención memoria, problemas para leer con fibromialgia, problemas para leer con lupus, problemas para leer con síndrome de fatiga crónica, problemas para leer con síndrome sjögren, libros fáciles de leer, problemas de memoria en fibromialgia, problemas de memoria en lupus, problemas de memoria en síndrome de fatiga crónica, problemas de memoria en síndrome de sjögren, trucos para leer mejor, leer sin distracciones, leer con brainfog, leer con niebla cerebral, leer con fibroniebla, leer con niebla lúpica,
#CognitiveDysfunction #Myalgicencephalomyelitis #LongCovid #chronicillness
"For me, looking back at my life with mild ME/CFS and mild brain fog, I had many cognitive issues. The most stark of which was a pretty severe loss of long and short term memory. It was as if my past was starting to be wiped clean, I simply could not access my memories and was often drawing a blank when people referred to experiences we had together; I couldn’t remember them at all."
https://www.whitneydafoe.com/mecfs/?post=what-does-brain-fog-feel-like
www.whitneydafoe.comWhat Does Brain Fog Feel Like?What Does Brain Fog Feel Like?
I self censor A LOT of my thoughts on here. I may want to reply but it can be very hard to know what to say that would be helpful, and kind, and also strike the right tone.
That's why I often just click the star (favourite) button and don't reply. At least then folks know that their comment was seen and appreciated.