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Victoria Stuart 🇨🇦 🏳️‍⚧️... cont'd 1/2* regulator protein CMTM6 inhibits degradation of both CD58 (stimulates T cell activity) & cell surface protein PD-L1 (inhibits T cell activity) * CD58 & PD-L1 compete for binding to regulator protein CMTM6 * tumor cell that express less CD58 free up more CMTM6 to stabilize PD-L1The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunity <a href="https://www.sciencedirect.com/science/article/abs/pii/S1535610823001812" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.sciencedirect.com/science/article/abs/pii/S1535610823001812</a> <a href="https://www.biorxiv.org/content/10.1101/2022.03.21.485049v1" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.biorxiv.org/content/10.1101/2022.03.21.485049v1</a>* cancer immune evasion ...<a href="https://mastodon.social/tags/melanoma" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#melanoma</a> <a href="https://mastodon.social/tags/CD58" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CD58</a> <a href="https://mastodon.social/tags/CMTM6" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CMTM6</a> <a href="https://mastodon.social/tags/PDL1" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PDL1</a>

Victoria Stuart 🇨🇦 🏳️‍⚧️Cancer Cloaking Device Revealed <a href="https://www.cancer.columbia.edu/news/cancers-cloaking-device-revealed" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.cancer.columbia.edu/news/cancers-cloaking-device-revealed</a> Discussion: <a href="https://news.ycombinator.com/item?id=37042790" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://news.ycombinator.com/item?id=37042790</a>* Malignant melanoma (skin cancer) deploys elegant molecular mechanism to evade natural immune responses, therapies * immune system eliminates abnormal cells; cancers can elude it * tumor cells that suppressed cell surface protein CD58 expression better at escaping immune surveillance * hinted at how melanomas might be hiding f. T cells ...<a href="https://mastodon.social/tags/cancer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cancer</a> <a href="https://mastodon.social/tags/melanoma" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#melanoma</a> <a href="https://mastodon.social/tags/CD58" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CD58</a> <a href="https://mastodon.social/tags/CMTM6" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CMTM6</a> <a href="https://mastodon.social/tags/PDL1" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PDL1</a> <a href="https://mastodon.social/tags/Tcells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Tcells</a> <a href="https://mastodon.social/tags/ImmuneSystem" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ImmuneSystem</a>

halama_immuno<a href="https://mstdn.science/tags/cytokines" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cytokines</a> as <a href="https://mstdn.science/tags/biomarkers" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#biomarkers</a> for therapeutic success in <a href="https://mstdn.science/tags/NSCLC" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#NSCLC</a> <a href="https://mstdn.science/tags/nsclctrial" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#nsclctrial</a> <a href="https://mstdn.science/tags/Immunotherapy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunotherapy</a> <a href="https://mstdn.science/tags/pd1" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#pd1</a> <a href="https://mstdn.science/tags/pdl1" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#pdl1</a> utilizing <a href="https://mstdn.science/tags/MachineLearming" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#MachineLearming</a> , link to downloadable PDF <a href="https://bit.ly/3NTxfTt" rel="nofollow noopener noreferrer" target="_blank">https://bit.ly/3NTxfTt</a>

Dan ChenIncredibly moving to see the positive results for IMbrave050, Tecentriq+Avastin in early stage HCC. Continues to highlight the relationship between <a href="https://mastodon.world/tags/VEGF" class="mention hashtag" rel="tag">#VEGF</a> and <a href="https://mastodon.world/tags/PDL1" class="mention hashtag" rel="tag">#PDL1</a> <a href="https://mastodon.world/tags/cancer" class="mention hashtag" rel="tag">#cancer</a> <a href="https://mastodon.world/tags/immunotherapy" class="mention hashtag" rel="tag">#immunotherapy</a> <a href="https://mastodon.world/tags/HCC" class="mention hashtag" rel="tag">#HCC</a> @genentech @Roche <a href="https://www.gene.com/media/press-releases/14981/2023-01-18/genentechs-tecentriq-plus-avastin-is-the" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://www.gene.com/media/press-releases/14981/2023-01-18/genentechs-tecentriq-plus-avastin-is-the</a>

Rio SugimuraBeginning now. Looking forward to giving a talk of <a href="https://med-mastodon.com/tags/Organoids" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Organoids</a> and <a href="https://med-mastodon.com/tags/PDL1" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PDL1</a> works @hkumed@twitter.com

Dan ChenThis is an excellent landscape map for <a href="https://mastodon.world/tags/cell" class="mention hashtag" rel="tag">#cell</a> <a href="https://mastodon.world/tags/therapy" class="mention hashtag" rel="tag">#therapy</a> <a href="https://mastodon.world/tags/immunotherapy" class="mention hashtag" rel="tag">#immunotherapy</a> <a href="https://mastodon.world/tags/CART" class="mention hashtag" rel="tag">#CART</a> <a href="https://mastodon.world/tags/TCR" class="mention hashtag" rel="tag">#TCR</a> <a href="https://mastodon.world/tags/cancer" class="mention hashtag" rel="tag">#cancer</a>. Created by Wells Fargo IG and Posted recently to LI by Basem Goueli. As noted by Jun Tang, The graphic concept originated from Vanessa Lucey from CRI and @IraMellman and I published on it for <a href="https://mastodon.world/tags/PDL1" class="mention hashtag" rel="tag">#PDL1</a> <a href="https://mastodon.world/tags/PD1" class="mention hashtag" rel="tag">#PD1</a> in Nature in 2018 as part of the Immune set point manuscript. Incredible how the field has developed over the last several years.

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