Today is international #LongCovid Awareness Day

Check this canadian interview with a Mount Sinai (NY) chronic disease specialist. Up to one in five people with COVID-19 develop LONG COVID, meaning three months after having the disease they still do not recover their full abilities.

The specialist affirms that each reinfection, even moderate, of COVID-19 subtracts between 2-6% of IQ.

LONG COVID is a disease that causes systemic damage, especially to the immune system, causing T-cell exhaustion and triggering latent diseases or exposing the body to new pathogens from which it would have been able to defend itself before. Worth a listen:

https://www.cbc.ca/player/play/audio/9.6685208

#CovidLong #COVID19 #CovidIsNotOver #COVIDisAirborne
#CovidIsntOver
#ImmuneSystem #ImmuneDysfunction
#autoimmune #TCell
#chronicillness
#ChronicIllnesses

Innate #ImmuneCells Develop Memory with a #TCell Marker;
#Human innate #immune #cells that “remember” previous stimulation could provide new insights into #chronic #inflammatory #diseases.

https://www.the-scientist.com/innate-immune-cells-develop-memory-with-a-t-cell-marker-72207

Exciting new findings about tissue-resident memory T cells and Epstein-Barr virus infection now published in @jci_insight

These findings shed light on a potential mechanism explaining why individuals with acute infectious mononucleosis maintain high viral loads in saliva while being able to control the infection in the blood.

You can read the in-press preview of the paper here: https://doi.org/10.1172/jci.insight.173489

#MedicalResearch #JCIInsight #EBV #InfectiousMononucleosis #Tcell #Immunology

DATE: September 12, 2024 at 07:00AM
SOURCE: BioWorld MedTech

Direct article link at end of text block below.

Autoimmune T cells may be beneficial for CNS injuries

https://t.co/vj2k9DtKW1

#medtech #tcell #CNS #cnsinjury

Here are any URLs found in the article text:

https://t.co/vj2k9DtKW1

#medtech

Articles can be found by scrolling down the page at https://www.bioworld.com/topics/85-bioworld-medtech .

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DATE: September 11, 2024 at 05:00PM
SOURCE: BioWorld MedTech

Direct article link at end of text block below.

Autoimmune T cells may be beneficial for CNS injuries

https://t.co/vj2k9DtKW1

#medtech #tcell #CNS #cnsinjury

Here are any URLs found in the article text:

https://t.co/vj2k9DtKW1

#medtech

Articles can be found by scrolling down the page at https://www.bioworld.com/topics/85-bioworld-medtech .

-------------------------------------------------

Private, vetted email list for mental health professionals: https://www.clinicians-exchange.org
.
NYU Information for Practice puts out 400-500 good quality health-related research posts per week but its too much for many people, so that bot is limited to just subscribers. You can read it or subscribe at @PsychResearchBot
.
Since 1991 The National Psychologist has focused on keeping practicing psychologists current with news, information and items of interest. Check them out for more free articles, resources, and subscription information: https://www.nationalpsychologist.com
.
EMAIL DAILY DIGEST OF RSS FEEDS -- SUBSCRIBE:
http://subscribe-article-digests.clinicians-exchange.org
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Profiling #SARS-CoV-2-specific #Tcell response, Lancet Infect Dis. {Correspondence}, https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(24)00377-3/fulltext?rss=yes

#Omicron subvariants that escape #antibody-mediated neutralisation are still recognised by cross-reactive T-cells, & should not be considered antigenically distinct by definition. Vaccination with a monovalent #XBB.1.5 vaccine boosted T-cell responses, including T cells that were cross-reactive with #variants that emerged after XBB.1.5.

... specific functional expression programs correlated with fluctuations in various #Tcell subsets, which may be associated with #AML progression and relapse. Furthermore, our analysis of cellular communication networks led to the identification of #VISTA, #CD244, and #TIM3 as potential #immunotherapeutic targets in pediatric AML."

https://pubmed.ncbi.nlm.nih.gov/38844062/

Nice work by Yuan et al., using #scRNAseq and #scTCRseq. No huge discoveries, but of interest nonetheless.

#Asthma treated in #mice using offshoot of #CAR #TCell #cancertherapy

https://www.newscientist.com/article/2432859-asthma-treated-in-mice-using-offshoot-of-car-t-cell-cancer-therapy/?utm_campaign=RSS%7CNSNS&utm_source=NSNS&utm_medium=RSS&utm_content=news

Our spin-off "Captain T Cell" raised €8.5 million in seed funding. Focused on developing T cells to target solid #tumors, Captain T Cell intends to use the funds to move a new generation of #Tcell therapies closer toward clinical application.

The #startup builds on years of research and innovations. It utilizes technologies developed at the #mdcBerlin, which provided financial and infrastructural support throughout the pre-seed phase and remains a close partner.

https://www.mdc-berlin.de/news/news/captain-t-cell-secures-seed-financing-round

Unraveling the Significance of CD4: A Key Marker in Immunology

#CDMarker, #CD4, #CD4Marker, #Cytokine, #CytokineProduction, #HelperCell, #ImmuneCell, #Immunity, #TCell #Immunology In the intricate landscape of immunology, CD4 stands out as a fundamental marker, pivotal in orchestrating the body’s defense mechanisms…. Medical Microbiology & Recombinant DNA Technology (RDT) Labs | Read More -

https://micrordt.wordpress.com/2024/05/16/unraveling-the-significance-of-cd4-a-key-marker-in-immunology/

"There's never been a time as good as nowadays to develop a scientific career for women," says our group leader Uta Höpken in our #WomenInSTEM interview. Her lab focuses on "Microenvironmental Regulation in Autoimmunity and #Cancer." She's also co-founder of CARTemis Therapeutics.

https://www.youtube.com/watch?v=8-lBn9LJB_A

More about Uta Höpken and her research: https://www.mdc-berlin.de/news/news/trainer

Or check out how CARTemis wants to use novel CAR #Tcell therapies: https://lnkd.in/eAm4mGSf

#LongCOVID manifests with #Tcell dysregulation, inflammation and an uncoordinated adaptive immune response to #SARSCoV2 | Nature #Immunology https://www.nature.com/articles/s41590-023-01724-6 https://bird.makeup/users/crabbbrendan/statuses/1745709258803655129

CAR T Cell Immunotherapy And The Quiet Hope For a Universal Cancer Treatment

#hackadaycolumns #science #cancer #cartcelltherapy #immunotherapy #tcell #hackaday

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hackaday.com/2023/11/27/car-t-…

I tried to avoid channels and #go routines for my little project using #tcell, but it has gotten to the point I cannot avoid it any more.

So here goes!

#TCell Cross-reactivity in Autoimmune-like Hepatitis Triggered by #COVID19 - ScienceDirect https://www.sciencedirect.com/science/article/pii/S2949928323000093 “Thus, we hypothesized that following #SARSCoV2 infection or vaccination, T cells carrying TCRs that recognize self-antigens undergo clonal expansion, which could eventually result in the onset of #autoimmune-like #hepatitis “

New #spinoff CARTemis Therapeutics founded: Uta Höpken, Armin Rehm, Anthea Wirges and Mario Bunse want to use novel CAR #TCell therapies to help patients with #cancers that are currently untreatable.

https://www.mdc-berlin.de/news/news/starting-highly-promising-immunotherapies

“Here we show that #catecholamines contribute to the progression of #CD8+ #Tcell exhaustion in #ChronicViralInfection and #cancer through the β1-adrenergic receptor #ADRB1.” https://mstdn.social/@erictopol/111098674708586754

Linfocito T citotóxico atacando repetidas veces a una célula cancerosas y acabando con ella. Así actuarían en la terapia de células T con receptores quiméricos de antígenos (CAR-T), donde se las modifica en laboratorio para que ataquen células cancerosas. #tcell #celulas #cells #salud #health Jeroen Slaats