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#neurodevelopment

4 posts3 participants1 post today
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Christian Mayer

Our research is now supported by a 2024 Simons Foundation Autism Research Initiative (SFARI) Pilot Award, co-funded by the Nancy Lurie Marks Family Foundation (NLMFF). I am grateful to both SFARI and NLMFF for investing in high-risk, high-reward science to advance understanding of autism spectrum disorders (ASD) and neurodevelopmental disorders.

The project will explore how mutations in chromatin regulators ASH1L and SETBP1 impair their crucial role in guiding the development of GABAergic neurons—key cells maintaining the brain’s balance between excitation and inhibition. Disruptions in this process are strongly linked to ASD, but the molecular pathways remain poorly understood.

By integrating genomic, proteomic, and functional approaches, we aim to reveal how these enzymes regulate gene activity during inhibitory neuron development and how their dysfunction contributes to ASD.

Official announcements:
SFARI: sfari.org/2025/04/08/announcin
NLMFF: nlmfoundation.org/grant/epigen

SFARI · SFARI | Announcing the Recipients of the 2024 Pilot and Pilot Progression AwardsThe Simons Foundation Autism Research Initiative is pleased to announce funding for 23 projects as part of its 2024 Pilot and Pilot Progression awards.
#newsmayerlab#SFARI#NLMFF
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