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#twinstudies
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What studies do you know of with twin #MRI data available to researchers (any age)? (ABCD obvious start). Bonus points for longitudinal data #science #twinstudies #neuroscience
Some identical (monozygotic) twins are not really identical. #monozygotictwins #identicaltwins #twinstudies #postgenomicmutations
"monozygotic twins differ on average by 5.2 early developmental mutations and approximately15% of monozygotic twins have a substantial number of these early developmental mutations specific to one of them."
https://www.nature.com/articles/s41588-020-00755-1.epdf
www.nature.comDifferences between germline genomes of monozygotic twins | Nature GeneticsDespite the important role that monozygotic twins have played in genetics research, little is known about their genomic differences. Here we show that monozygotic twins differ on average by 5.2 early developmental mutations and that approximately 15% of monozygotic twins have a substantial number of these early developmental mutations specific to one of them. Using the parents and offspring of twins, we identified pre-twinning mutations. We observed instances where a twin was formed from a single cell lineage in the pre-twinning cell mass and instances where a twin was formed from several cell lineages. CpG>TpG mutations increased in frequency with embryonic development, coinciding with an increase in DNA methylation. Our results indicate that allocations of cells during development shapes genomic differences between monozygotic twins. Whole-genome sequencing of monozygotic twins, along with their parents, spouses and children, identifies postzygotic mutations present in the somatic tissue of one twin, but not the other, and characterizes differences in the number and timing of these mutations.