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PLOS BiologyMultiple <a href="https://fediscience.org/tags/myeloma" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#myeloma</a> often requires IRE1 to sustain malignant growth, but why? This study shows that IRE1 promotes <a href="https://fediscience.org/tags/CellCycle" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CellCycle</a> progression via the transcription factor IRF4, paving the way for new therapeutic strategies <a href="https://fediscience.org/@PLOSBiology" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@PLOSBiology</a> <a href="https://plos.io/43TnG0L" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://plos.io/43TnG0L</a>

PLOS BiologyER-resident IRE1 plays a role in <a href="https://fediscience.org/tags/cancer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cancer</a> development via enzymatic activation of XPB1 TFs and regulated <a href="https://fediscience.org/tags/RNAdecay" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#RNAdecay</a>. This study shows that some cancer cells also have an unexpected nonenzymatic dependency on IRE1 to promote <a href="https://fediscience.org/tags/CellCycle" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CellCycle</a> progression & tumor growth <a href="https://fediscience.org/@PLOSBiology" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@PLOSBiology</a> <a href="https://plos.io/3EaNFX4" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://plos.io/3EaNFX4</a>

PLOS BiologyCurrent methods to study <a href="https://fediscience.org/tags/CellCycle" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CellCycle</a> progression in <a href="https://fediscience.org/tags/yeast" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#yeast</a> ignore variations in cell size. The FLCCR reporter system can quantify the duration of cell cycle phase in single cells, allowing independent assessment of cell size & cell cycle progression <a href="https://fediscience.org/tags/plosbiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#plosbiology</a> <a href="https://plos.io/4j48NxJ" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://plos.io/4j48NxJ</a>

Andrew MillarFrom post 5, Amino acids that are enriched/depleted next to the phospho-site reflect which protein kinase enzymes did the phosphorylation. Phospho-dawn sees acid-directed sites being phosphorylated (D and E enriched at ZT0), but by evening it's <a href="https://fediscience.org/tags/CellCycle" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CellCycle</a> kinases guided by Proline (P at ZT12-16). 😎 <a href="https://fediscience.org/tags/Shiftwork" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Shiftwork</a>

PLOS BiologyApicomplexan <a href="https://fediscience.org/tags/parasite" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#parasite</a> division: @MGissot &co show that the <a href="https://fediscience.org/tags/phosphatase" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#phosphatase</a> TgPP1 in <a href="https://fediscience.org/tags/Toxoplasma" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Toxoplasma</a> regulates the <a href="https://fediscience.org/tags/CellCycle" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CellCycle</a> & amylopectin accumulation by dephosphorylating inner membrane complex & starch-binding domain proteins <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PLOSBiology</a> <a href="https://plos.io/3XwMYgj" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://plos.io/3XwMYgj</a>

PLOS BiologyHow do cells respond to defects in nuclear reassembly after <a href="https://fediscience.org/tags/mitosis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#mitosis</a>? This study in <a href="https://fediscience.org/tags/Drosophila" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Drosophila</a> shows that damaged cells are either removed by <a href="https://fediscience.org/tags/apoptosis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#apoptosis</a> or activate a p53-dependent <a href="https://fediscience.org/tags/CellCycle" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CellCycle</a> checkpoint to maintain tissue integrity <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PLOSBiology</a> <a href="https://plos.io/3AA4g4c" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://plos.io/3AA4g4c</a>

preLights“In this preprint, the authors (Saykali et al.) turned into cinematographers, capturing the real time dynamics of CDKs using a very sensitive sensor.” 🎬 🎥Another lovely, entertaining preLight prepared by Mansi - check it out! ⬇️ 👀<a href="https://biologists.social/tags/preLight" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#preLight</a> 👉 <a href="https://prelights.biologists.com/highlights/lineage-specific-cdk-activity-dynamics-characterize-early-mammalian-development/" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://prelights.biologists.com/highlights/lineage-specific-cdk-activity-dynamics-characterize-early-mammalian-development/</a><a href="https://biologists.social/tags/development" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#development</a> <a href="https://biologists.social/tags/biology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#biology</a> <a href="https://biologists.social/tags/preprint" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#preprint</a> <a href="https://biologists.social/tags/cellcycle" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cellcycle</a> <a href="https://biologists.social/tags/imaging" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#imaging</a>

Haojia WuQuantifying DNA replication speeds in single cells by scEdU-seq <a href="https://mastodon.haojia-wu.com/tags/singlecell" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#singlecell</a> <a href="https://mastodon.haojia-wu.com/tags/cellcycle" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cellcycle</a> <a href="https://mastodon.haojia-wu.com/tags/newtech" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#newtech</a> <a href="https://www.nature.com/articles/s41592-024-02308-4?utm_source=nmeth_etoc&utm_medium=email&utm_campaign=toc_41592_21_7&utm_content=20240713" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.nature.com/articles/s41592-024-02308-4?utm_source=nmeth_etoc&utm_medium=email&utm_campaign=toc_41592_21_7&utm_content=20240713</a>

micrordtUnraveling the Mechanisms: Regulation of DNA Replication in Bacterial Cells<a href="https://mastodon.social/tags/Bacteria" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Bacteria</a>, <a href="https://mastodon.social/tags/CellCycle" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CellCycle</a>, <a href="https://mastodon.social/tags/DNA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#DNA</a>, <a href="https://mastodon.social/tags/DNAReplication" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#DNAReplication</a>, <a href="https://mastodon.social/tags/DnaA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#DnaA</a>, <a href="https://mastodon.social/tags/OriC" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#OriC</a>, <a href="https://mastodon.social/tags/RegulatoryProteins" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#RegulatoryProteins</a>, <a href="https://mastodon.social/tags/Replication" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Replication</a> <a href="https://mastodon.social/tags/Genetics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Genetics</a>, <a href="https://mastodon.social/tags/MolecularBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#MolecularBiology</a> DNA replication is a fundamental process in all living organisms, ensuring the faithful transmission of genetic information from one generation to the next. In bacterial cells, where simplicity meets efficiency…. Medical Microbiology & Recombinant DNA Technology (RDT) Labs…<a href="https://micrordt.wordpress.com/2024/05/01/unraveling-the-mechanisms-regulation-of-dna-replication-in-bacterial-cells/" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://micrordt.wordpress.com/2024/05/01/unraveling-the-mechanisms-regulation-of-dna-replication-in-bacterial-cells/</a>

PLOS BiologyCell cycle genes are re-activated in some <a href="https://fediscience.org/tags/neurons" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#neurons</a> as our brains age. This study uses bioinformatics to characterize the prevalence, nature & fate of these <a href="https://fediscience.org/tags/CellCycle" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CellCycle</a> re-entry neurons, within the healthy <a href="https://fediscience.org/tags/aging" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#aging</a> & diseased human brain. <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PLOSBiology</a> <a href="https://plos.io/4dbHoXt" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://plos.io/4dbHoXt</a>

Andrew BurgessWhen you have “ATM” in your name your destiny is to either work for a bank or become a researcher specialising in <a href="https://mastodon.social/tags/DNAdamage" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#DNAdamage</a> <a href="https://mastodon.social/tags/science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#science</a> <a href="https://mastodon.social/tags/CellCycle" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CellCycle</a><a href="https://pubmed.ncbi.nlm.nih.gov/38625790/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=1TkPOxkdaxtnnrl5wnZzn2VRNhPyzrYC_QUuJ0PP1Pdf91LMB7&fc=None&ff=20240416205101&v=2.18.0.post9+e462414" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://pubmed.ncbi.nlm.nih.gov/38625790/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=1TkPOxkdaxtnnrl5wnZzn2VRNhPyzrYC_QUuJ0PP1Pdf91LMB7&fc=None&ff=20240416205101&v=2.18.0.post9+e462414</a>

PLOS BiologyProliferating cells need to maintain a stable size distribution across the generations. This study shows that this is achieved by tightly controlling <a href="https://fediscience.org/tags/CellSize" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CellSize</a> variation throughout the <a href="https://fediscience.org/tags/CellCycle" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CellCycle</a>, mainly via regulation of cell growth rate <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PLOSBiology</a> <a href="https://plos.io/4aMUWHS" rel="nofollow noopener noreferrer" target="_blank">https://plos.io/4aMUWHS</a>

The EMBO JournalHow do <a href="https://sciencemastodon.com/tags/cellcycle" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cellcycle</a> oscillators generate exactly two <a href="https://sciencemastodon.com/tags/meiotic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#meiotic</a> divisions for production of haploid <a href="https://sciencemastodon.com/tags/gametes" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#gametes</a>? Wolfgang Zachariae and colleagues show that <a href="https://sciencemastodon.com/tags/Spo13" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Spo13</a>/#MEIKIN and <a href="https://sciencemastodon.com/tags/Cdc5" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Cdc5</a>/#Plk1 cooperate to prevent premature APC/C-<a href="https://sciencemastodon.com/tags/Ama1" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Ama1</a> activation after <a href="https://sciencemastodon.com/tags/meiosis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#meiosis</a> I <a href="https://www.embopress.org/doi/full/10.15252/embj.2023114288" rel="nofollow noopener noreferrer" target="_blank">https://www.embopress.org/doi/full/10.15252/embj.2023114288</a>

The EMBO Journal<a href="https://sciencemastodon.com/tags/Phosphorylation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Phosphorylation</a> control in <a href="https://sciencemastodon.com/tags/mitosis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#mitosis</a>: Julie Welburn and colleagues reveal the molecular basis for <a href="https://sciencemastodon.com/tags/cellcycle" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cellcycle</a> regulation of <a href="https://sciencemastodon.com/tags/Kif4A" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Kif4A</a> and <a href="https://sciencemastodon.com/tags/CENPE" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CENPE</a> motor interaction with <a href="https://sciencemastodon.com/tags/PRC1" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PRC1</a>, needed to organize antiparallel <a href="https://sciencemastodon.com/tags/microtubule" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#microtubule</a> bundles and to ensure central spindle integrity, <a href="https://sciencemastodon.com/tags/midbody" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#midbody</a> assembly and <a href="https://sciencemastodon.com/tags/cytokinesis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cytokinesis</a><a href="https://www.embopress.org/doi/full/10.15252/embj.2023113647" rel="nofollow noopener noreferrer" target="_blank">https://www.embopress.org/doi/full/10.15252/embj.2023113647</a>

Small Things Consideredcell 🚴‍♂️ cyclists & DNA replicationists take note 👇 super interesting thread by kristina jonas on twitter (X): <a href="https://twitter.com/krijonas/status/1684903480069128192" rel="nofollow noopener noreferrer" target="_blank">https://twitter.com/krijonas/status/1684903480069128192</a><a href="https://mstdn.science/tags/microbiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#microbiology</a> <a href="https://mstdn.science/tags/replication" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#replication</a> <a href="https://mstdn.science/tags/cellcycle" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cellcycle</a>

Small Things Consideredbacterial cell cyclists take note 👇 'The Nordström Question' by William D. Donachie. This will remain one of the most memorable papers I’ve ever read by the end of my career. — Suckjoon Jun <a href="https://bird.makeup/users/junlab_ucsd" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@junlab_ucsd</a>(<a href="https://twitter.com/junlab_ucsd/status/1673262090734141440" rel="nofollow noopener noreferrer" target="_blank">https://twitter.com/junlab_ucsd/status/1673262090734141440</a>)<a href="https://www.mdpi.com/2075-1729/13/7/1442" rel="nofollow noopener noreferrer" target="_blank">https://www.mdpi.com/2075-1729/13/7/1442</a><a href="https://mstdn.science/tags/microbiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#microbiology</a> <a href="https://mstdn.science/tags/cellcycle" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cellcycle</a>

The EMBO JournalA <a href="https://sciencemastodon.com/tags/transcription" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#transcription</a>-independent mechanism -<a href="https://sciencemastodon.com/tags/RBM10" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#RBM10</a>-mediated RNA alternative <a href="https://sciencemastodon.com/tags/splicing" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#splicing</a> coupled to nonsense-mediated <a href="https://sciencemastodon.com/tags/mRNA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#mRNA</a> decay- determines rapid periodic fluctuations of <a href="https://sciencemastodon.com/tags/BRCA1" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#BRCA1</a> expression throughout the <a href="https://sciencemastodon.com/tags/cellcycle" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cellcycle</a><a href="https://www.embopress.org/doi/full/10.15252/embj.2022111951" rel="nofollow noopener noreferrer" target="_blank">https://www.embopress.org/doi/full/10.15252/embj.2022111951</a>

Thiago Carvalho"In this study, we revisit and significantly extend the initiator-titration model, proposed thirty years ago, and explain how bacteria precisely and robustly control replication initiation based on the mechanism of protein copy-number sensing."<a href="https://qoto.org/tags/preprint" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#preprint</a> <a href="https://qoto.org/tags/microbiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#microbiology</a> <a href="https://qoto.org/tags/cellcycle" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cellcycle</a><a href="https://www.biorxiv.org/content/10.1101/2023.05.26.542547v1" rel="nofollow noopener noreferrer" target="_blank">https://www.biorxiv.org/content/10.1101/2023.05.26.542547v1</a>

eLifeTransferred <a href="https://fediscience.org/tags/mitochondria" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#mitochondria</a> accumulate reactive oxygen species, promoting proliferation. <a href="https://fediscience.org/tags/Cancer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Cancer</a> <a href="https://fediscience.org/tags/ReactiveOxygenSpecies" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ReactiveOxygenSpecies</a> <a href="https://fediscience.org/tags/CellCycle" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CellCycle</a> <a href="https://elifesciences.org/articles/85494?utm_source=mastodon&utm_medium=social&utm_campaign=organic" rel="nofollow noopener noreferrer" target="_blank">https://elifesciences.org/articles/85494?utm_source=mastodon&utm_medium=social&utm_campaign=organic</a>

Boris TefsenVery interesting work with implications beyond <a href="https://mas.to/tags/metabolism" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#metabolism</a> / <a href="https://mas.to/tags/biosynthesis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#biosynthesis</a> and cell cycle in <a href="https://mas.to/tags/yeast" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#yeast</a>. <a href="https://www.nature.com/articles/s42255-023-00741-x" rel="nofollow noopener noreferrer" target="_blank">https://www.nature.com/articles/s42255-023-00741-x</a> <a href="https://mas.to/tags/Microbiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Microbiology</a> <a href="https://mas.to/tags/CellCycle" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CellCycle</a> <a href="https://mas.to/tags/Proteins" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Proteins</a> <a href="https://mas.to/tags/Carbohydrates" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Carbohydrates</a> <a href="https://mas.to/tags/Lipids" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Lipids</a>

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