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#neuroscience

104 posts70 participants11 posts today

This paper by Raju et al. proposes a unified model – “clone‑structured causal #graphs” (#CSCG) – for #hippocampal #SpatialCoding. It suggests that #SpatialMaps arise from #learning #latent higher‑order sequences rather than representing #EuclideanSpace directly. The model elegantly explains phenomena like #PlaceFields, #SplitterCells, #contextual #remapping, and predicts when #PlaceFieldMapping may mislead.

🌍 science.org/doi/10.1126/sciadv

Neural and Behavioral Markers of Negative Symptoms and Cognitive Impairment in Patients with Psychosis

jneurosci.org/cgi/content/shor

Journal of Neuroscience · Neural and Behavioral Markers of Negative Symptoms and Cognitive Impairment in Patients with PsychosisNegative and cognitive symptoms impair functioning in patients with psychotic illnesses [i.e., schizophrenia spectrum disorders (SZ) and bipolar I disorder with psychotic features (BD)]. Disruptions in mesocorticolimbic circuitry are hypothesized to underpin negative symptoms and cognitive impairment in patients with psychosis and may also facilitate reward-motivational deficits. In male and female patients with psychosis ( N  = 44) and healthy controls (HC = 27), we used neuroimaging to define gray matter morphology and white matter microstructure. We examined negative symptom severity with the Clinical Assessment Interview for Negative Symptoms (CAINS), effort allocation during reward processing with the Effort Expenditure for Rewards Task (EEfRT), and cognitive performance with the MATRICS cognitive consensus battery (MCCB). Reduced nucleus accumbens volumes in patients with psychosis were associated with higher CAINS total and motivation and pleasure subscale scores as well as lower effort expenditure for medium (50%) and high (88%) reward probability conditions during EEfRT. The fornix showed reduced fractional anisotropy in patients with psychosis. Negative associations were present between CAINS motivation and pleasure subscores and MCCB composite and subscale scores. Lower gray matter volume in cerebellar Lobule IV corresponded with impaired effort allocation during medium and high reward probability conditions and lower cognitive performance. However, Lobule IV was not correlated with CAINS scores. While nucleus accumbens volume may serve as a marker of negative symptoms in psychotic illnesses, cerebellar Lobule IV morphology may inform on cognitive impairment in patients with SZ and BD. The nucleus accumbens and Lobule IV may each contribute to reduced effort allocation during reward processing.

And this is why everything we “see” is a hallucination emerging from our consciousness.

And our consciousness emerges from sensory inputs to our brains, and the fact that we are meat.

Corporeal.

There is no colour outside of our experience of it.

We are making it up.

Read @anilkseth

#neuroscience

mastodon.social/@samim/1148964

Mastodonsamim (@samim@mastodon.social)Attached: 1 image 'water is transparent only within a very narrow band of the electromagnetic spectrum, so living organisms evolved sensitivity to that band, and that's what we now call "visible light". '

A new study by Timothy Sit, Célian Bimbard, Anna Lebedeva, @MatteoCarandini, Philip Coen, and Kenneth Harris challenges the classic cortical column model. Using in vivo recordings, they show that layers 2/3 and 5 in #V1 encode distinct visual features — functionally dissociated, not redundant. A cool look into laminar specialization.

🌍 biorxiv.org/content/10.1101/20